Yana I Sandlers
 Title: Assistant Professor
 Dept: Chemistry
 Office: SR 364
 Phone: 216-687-2421,  216-687-2421
 Email: y.sandlers@csuohio.edu
 Address: 2121 Euclid Ave. SR 364, Cleveland, OH 44115

Courses Taught


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Research Keywords:
Clinical Chemistry, Mass Spectrometry, Inborn Errors of Metabolism, Metabolomics, induced stem cells derived cardiomyocytes (iPSCM), Barth syndrome, Cardiomyopathy
Postdoctoral fellowship, Nutritional Biochemistry, Case Western Reserve University, 2009
Brief Bio:
Dr.Sandlers joined Cleveland State University as Assistant Professor of Chemistry in 2014. Prior to this, she held an assistant director position with biochemical genetics diagnostic laboratory at Kennedy Krieger Institute (Baltimore, MD). Her research interests include clinical and biological mass spectrometry, clinical chemistry, laboratory medicine, metabolic cardiomyopathies and inborn errors of metabolism.
Creative and Activities:

1. Radzikh I and Sandlers (2019) DODA treatment in VLCAD fibrolasts SIMD 2019
2. Fatica.E and Sandlers. Y (2018) . Barth Syndrome-Probing cardiac metabolism with stable isotope tracers in iPSCM model. RCSIRM Metabolomics Symposium program, University Kentucky , Lexington
3. Fatica.E and Sandlers Y (2018). Unraveling new therapeutic targets in iPS model of Barth syndrome. Barth Syndrome Medical and Scientific Conference. Clearwater, FL
4. Fatica.E and Sandlers Y (2018). Investigating cardiac energy metabolism in Barth Syndrome using iPS-CM Molecular Genetics and Metabolism. Society of Inherited Metabolic Disorders Meeting. San Diego, CA
5. Fatica.E and Sandlers.Y (2018). Modeling Barth Syndrome Cardiac Phenotype with iPS-CM. Society of Inherited Metabolic Disorders Meeting. San Diego, CA
6. M.Gangadhariah, A. Allawy, G.Davuluri, A. Kumar, S.Kant, K.Alsabbagh, R. Shah*, T.Kasumov, Y.Sandlers, S.Dasarathy. (2018). Hyperammonemia Induced Redox Changes in Skeletal Muscle Perturbs Glucose-Pyruvate Metabolism and Tissue Bioenergetics¿. American Association for the Study of Liver¿Diseases (AASLD) meeting , San Francisco, CA
7. A. Allawy,¿D.Singh,¿ C.Tsien,¿Rohan R. Shah,¿K. A. Alchirazi,¿R. O'Shea,¿A. J. McCullough,¿ J. Dasarathy,¿ G Davuluri,¿Y.Sandlers,¿ S. Dasarathy. (2017) Serum tricarboxylic acid cycle intermediates: potential biomarker for hyperammonemic metabolic dysregulation in human cirrhosis. Poster Abstract presented at the 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Washington , DC.
8. A. Allawy,¿A. Kumar, R.Shan*. Alchirazi,K. Alsabbagh; Y.Sandlers,D.Gangarao S. Dasarathy. (2017) L-leucine supplementation reverses hyperammonemia induced skeletal muscle mitochondrial dysfunction. Poster Abstract presented at the 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Washington , DC
9. R. Shah, A. House, E.Fatica, Y.Sandlers (2017). Development of combined LC-MS/MS analysis for Citric Acid Cycle Intermediates, Acylcarnitines and Amino Acids. American Society for Mass Spectrometry, Indianapolis, IN
10. H. Vernon, R.Thompson,B. DeCroes, R.McClellan, K.Mercier, W.Pathmasiri, S. Dhungana, and J.Carlson, S. McRitchie, S. Sumner, Y. Sandlers. (2015) Clinical, molecular, and metabolomic studies reveal targets for therapy and new mechanisms of pathology in Barth Syndrome. American Society of Human Genetics meeting, Baltimore, MD
11. A. Allawy,¿A. Kumar, Alchirazi, K. Alsabbagh, R.Shah, Y.Sandlers,D.Gangarao S. Dasarathy. (2015) Cataplerosis of ¿-ketoglutarate during skeletal muscle hyperammonemia contributes to impaired TCA cycle intermediates . Poster Abstract presented at the 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, MA
12. Sandlers.Y and Kelley.R (2014) Plasma citric acid cycle intermediates levels by LC-MS/MS a prospective application in diagnosis of mitochondrial disorders. American Society for Mass Spectrometry, Baltimore, MD

13. Victor.K, Sandlers. Y and Vernon H. Acylcarnitine profiles indicate subtle differences in biochemistry in Methyl Malonic Acidemia and Proprionic Acedimia.(2014) American Society of Human Genetics meeting, Nashville, TN
14. Sandlers.Y and Kelley R. (2014) Decreased levels of plasma L-Arginine and Arginine dimethylated analogues in Barth Syndrome patients Barth Syndrome meeting, Clearwater, FL
15. Vernon H, Cordova A, McClean R, Kelley R and Sandlers Y (2013) Biochemical and hematologic laboratory studies in a cohort of patients with Barth Syndrome, American Society of Human Genetics meeting
16. H.Vernon, Y.Sandlers, R.Kelley and D.Valley (2011) Identification of novel biochemical abnormalities in organic acidemias through GC¿MS based metabolomics approach. International Congress of Human Genetics, Montreal ,Canada
17. Characterization of urine metabolites in Barth syndrome patients employing a no
Teaching Areas:
Clinical Chemistry, Biochemistry
Professional Experience:
2009-2014 Assistant Director, Biochemical Genetics Laboratory-Metabolism Division. Kennedy Krieger Institute, Baltimore MD

2014- Present Assistant Professor, Department of Chemistry , Cleveland State University