Tobili Yvonne Sam-Yellowe, PhD, MPH
 Title: Professor
 Dept: Biological, Geological and Environmental Sciences
 Office: SR 257
 Phone: 216-687-2068,  216-687-2482
 Fax: 216-687-697
 Address: 2121 Euclid Ave. SR 257, Cleveland, OH 44115

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Ph.D., University of Montana
Brief Bio:
BS      Microbiology, University of Oklahoma 1979
MS      Microbiology, University of Oklahoma 1981
PhD      Microbiology, University of Montana 1986
Postdoc              Biochemical Parasitology, The Rockefeller University 1986-1990
MPH                  Public Health, Cleveland State University 2009
Certificate        Advanced Study in Bioethics, Cleveland State University 2009
Honors and Awards:
Fogarty International Center of the U.S., NIH, Minority International Training (MIRT) Program, University of Edinburgh, Edinburgh, Scotland UK 1996

Fogarty International Center of the U.S., NIH, Course on ¿Vectors and Vector Borne Diseases in Africa¿, Bamako, Mali 1997

New England Biolabs Molecular Biology Summer Workshops, Smith College, Northampton, MA 2000

National Science Foundation Chautauqua Short Course ¿Updating Immunology¿
Whitehead Institute, Cambridge, MA 2001

National Institutes of Health (R21), 2005-2007

Cleveland State University Established Full-time Faculty Research Development Program (EFFRD), 2005-2007
Research Interests:
Malaria immunology, cell biology and molecular biology

A major research area in my lab involves investigations of the role of rhoptry proteins in erythrocyte binding and invasion by Plasmodium merozoites. Investigations include: proteome analysis of the merozoite rhoptries, study of the immune response to rhoptry proteins & identification of determinants of blood stage immunity to Plasmodium in murine models, development of diagnostic biomarkers for malaria and mechanisms of the formation and function of the parasitophorous vacuole during intracellular blood stage development of Plasmodium. Rhoptries are specialized organelles found in invasive stages of Apicomplexan parasites such as in Plasmodium sp, the causative agent of malaria. Rhoptry proteins released during merozoite attachment and invasion into the host erythrocyte aid in the formation of the tight junction and parasitophorous vacuole. We investigated the composition of the rhoptry organelle using antibody production against isolated rhoptries and also by multidimensional protein identification technology (MudPIT) using isolated rhoptries. We identified novel proteins within the organelle that we are currently characterizing with the aim of identifying genes encoding proteins that participate in merozite invasion, parasitophorous vacuole formation, development of blood stage immunity and the identification of motifs critical to binding and host cell invasion shared among invasive stages (zoites) within the Apicomplexa.
A second area of interest in the lab is macromolecular trafficking within the infected erythrocyte. We continue to investigate the Maurer¿s clefts (MCs), structures that are formed as part of an elaborate intracellular membrane network in Plasmodium falciparum- infected red blood cells. Proteins destined to secretory compartments within the infected erythrocyte and to the surface of the infected erythrocyte are transported through this network. Using proteome analysis of immune complexes, we identified a novel multigene family; PfMC-2TM that encodes proteins located in the MCs. We continue to investigate this new gene family to understand the mechanisms of protein traffic within the infected erythrocyte, the role of PfMC-2TM proteins in protein traffic and formation & maintenance of the MCs during the blood stage of P. falciparum.
Teaching Areas:
Human Biology in Health and Disease
Cell Biology
Professional Experience:
Postdoctoral Associate Biochemical Parasitology, The
Rockefeller University, New York, NY (Laboratory of Dr.
Margaret Perkins, 1986-1990).
Professor of Biology Cleveland State University 1990 to present
Adjunct Faculty Department of Immunology, Lerner Research Institute of the Cleveland Clinic Foundation. 1998 to present
Faculty Department of Life Sciences, International
Space University, Cleveland Summer Session, June 17- August 22, 1998. Topic: ¿Microbes and Microgravity¿