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Aimin Zhou
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Title: |
Professor
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Dept: |
Chemistry |
Office: |
SI 424 |
Phone: |
216-687-2416 |
Email: |
A.ZHOU@csuohio.edu
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Address: |
2121 Euclid Ave. SI 424, Cleveland, OH 44115 |
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Research Keywords: |
| Interferon,
RNase L,
Inflammatory diseases,
Gene expression |
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Education: |
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B.S., Organic chemistry, Zhongshan University, 1982
M.S., Biochemistry, Institute of Microbiology,CAS, 1985
Ph.D., Clinical Chemistry, Cleveland State University, 1998
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Brief Bio: |
| 2012-present:Professor, Clinical Chemistry Program,
Department of Chemistry, Cleveland State University, Cleveland, Ohio
2005-2012: Associate Professor, Clinical Chemistry Program,
Department of Chemistry, Cleveland State University, Cleveland, Ohio
2000-2005: Assistant Professor, Clinical Chemistry Program,
Department of Chemistry,Cleveland State University, Cleveland, Ohio
1998-2000: Project Scientist, Department of Cancer Biology,
Cleveland Clinic Foundation,Cleveland,Ohio
1994-1998: Research Associate, Department of Cancer Biology,
Cleveland Clinic Foundation, Cleveland, Ohio
1991-1994: Research Fellow, Department of Cancer Biology,
Cleveland Clinic Foundation, Cleveland, Ohio
1987-1991: Visiting Scientist, Department of Pathology,
Uniformed Services University of the Health Sciences,
Bethesda, Maryland
1985-1987: Research Fellow, Department of Enzymology,
Institute of Microbiology, The Chinese Academy of
Sciences, Beijing, China |
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Honors and Awards: |
| 2019-2020 Merit Recognition Award
Cleveland State University
2014 Distinguished Faculty Research Award, Cleveland State University
2010-2016 Merit Recognition Award, Cleveland State University
2010 Outstanding Achievement Award
Chinese American Faculty and Staff Association
Cleveland State University
2008/2009 Merit Recognition Award, Cleveland State University
2007 Merit Recognition Award, Cleveland State University
2006 Merit Recognition Award, Cleveland State University
6/1991 : Sustained Superior Performance Award
Henry M. Jackson Foundation
for the Advancement of Military Medicine
Bethesda, Maryland
1988-1989: Outstanding Performance Award
Uniformed Services University of the Health Sciences
Bethesda, Maryland
1987-1988: Outstanding Performance Award
Uniformed Services University of the Health Sciences
Bethesda, Maryland |
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Research Interests: |
| RNase L is one of the key enzymes involved in the molecular mechanisms of interferon (IFN) function. Upon binding with its activator, 5'-phosphorylated and 2'-5' linked oligoadenylates (2-5A), RNase L plays an important role in the antiviral and anti-proliferative functions of IFN, and exerts proapoptotic activity independent of IFN. These biological activities are thought to occur through the RNase L-dependent regulation of RNA stability and expression; however, the molecular targets of RNase L remain largely unknown. Recently we have found that RNase L regulates the expression of several proinflammatory genes. Our research has focused on investigating the molecular mechanism by which RNase L regulates the expression of these proinflammatory genes and the role of RNase L in inflammatory diseases. |
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Teaching Areas: |
| Biotechnology
Clinical Chemistry
College Chemistry |
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Professional Affiliations: |
| American Association for the Advancement of Science
American Association for Clinical Chemistry
International Society for Interferon and Cytokine Research
American Cancer Society |
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